- triad of
i) upper airways (granuloma) - rhintis (first sign), epistaxis, sinusitis, saddle nose (perforated septum), otitis, mastoiditis
ii) lungs (granuloma and vasculitis) - multiple pulmonary nodule (coin lesions), cavitating lesion with diffuse alveolar changes, presents with hemoptysis
iii) renal (vasculitis)- segmental crescentric necrotizing glomerulonephritis
- c-ANCA (PR3) positive (highly sensitive and specific)
- treatment: IV methylprednisolone, cyclophosphamide
Poor prognostic indicators
- presence and severity of renal involvement
- elderly
- pulmonary hemorrhage
- poor response to therapy at 2 weeks
- high degree of sclerosed glomeruli/interstitial scarring on biopsy
1 comment:
I had my TL a little more than a year ago when my third child was born via c-section. I was not told ANYTHING about the possible side effects of having this procedure. Since then I have experienced heavy bleeding lasting sometimes 3 weeks out of the month, weight gain, severe mood swings. Severe cramping, changes to my libido, severe depression accompanied by suicidal thoughts, headaches, migraines, many new symptoms & older issues are now exacerbated. The father of two of my children doesn't want me anymore. I've become too much of a pain in the ass I guess. We don't talk. We don't sleep in the same bed. I think he might really think I am crazy... & maybe I am. I feel crazy a lot of the time.
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