- most common primary immunodeficiency
- typically present at any age with recurrent infections caused by pyogenic organisms and affecting mucosal sites
- can coexist with IgG2 deficiency
- deficient response to polysaccharide based vaccination
- predispose to pernicious anemia and thus gastric carcinoma
- increased risk of coeliac disease
- no specific treatment. Replacement is not practical as IgA has short half life
- Infusion of exogenous IgA (eg: blood transfusion) could result in anaphylaxis (10-44% of patients may have anti-IgA antibodies)
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