- focal and segmental proliferative glomerulonephritis with mesangial deposits of polymeric IgA
- associated with coeliac disease, cirrhosis and HIV infection
- IgA raised in 50% of cases
- tends to occur in children and young males, presents with asymptomatic microscopic hematuria or recurrent macroscopic hematuria following URTI/gastrointestinal viral infection (usually 1-2 days after URTI as opposed to PSGN which occur some time later) - synpharyngitic haematuria
- hypertension is associated with deteriorating renal function and thus worse prognosis
- prognosis usually good, but 25% risk of developing ESRF
- commonest primary glomerulonephritis leading to chronic renal failure
- treatment: steroid, ACE inhibitor and ARB
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