- characterised by lymphocytic infiltration of exocine glands
syndrome of dry eyes (keratoconjunctivitis sicca) in the absence of RA or any autoimmune disease
- associated with HLA-B8/DR3
- features
- arthralgia
- dry mough
- vaginal dryness
- Raynaud's phenomenon
- renal tubular acidosis
- increased incidence of lymphoma
- positive rheumatoid factor
- positive ANA
- anti-Ro (SSA) and anti-La (SSB) positive. Can cross placenta and causes congenital heart block.
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