Hypereosinophilic syndrome

- characterised by persistently elevated eosinophil count for at least 6 months with involvement of heart, CNS and bone marrow
- eosinophil count more than 1.5X10⁹/L
- presented with weight loss, rashes, fever, peripheral neuropathy, edema, cardiac disturbance
- exclude Strongyloides stercoralis (can cause hyperinfection syndrome if given steroid)
- 2 forms of heart involvement : endomyocardial fibrosis (Davies disease), Loeffler's endocarditis
- treatment: steroid and hydroxurea