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Sunday, 9 October 2011

SIADH inducing drugs

"ABCD"

A: analgesia (opioids, NSAIDs)
B: barbiturates
C: carbamazepine, cyclophosphamide, chlorpromazine
D: diuretics (thiazide)

other medications: vincristine, vinblastine, etc

- democlocycline can induce nephrogenic DI and thus can be used to treat SIADH

- criteria for diagnosis of SIADH includes normal renal, adrenal and thyroid function with hyponatraemia and hypotonic plasma (<270mOsmol/kg)

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