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Friday 30 December 2011

Trypanosomiasis

American trypanosomiasis (Chagas' disease)
- caused by T.cruzi
- spread by reduviids (triatomine bugs)
- erythematous indurated nodule (chagoma) at side of infection which may then scar
- fever, myalgia, rash, lymphadenopathy, hepatosplenomegaly, unilateral conjunctivitis, periorbital edema (Romana's sign), myocarditis, meningoencephalitis
- trypomastigotes seen or grown from blood in acute disease, serology in chronic disease
- treatment: nifurtimox, benznidazole

 

African trypanosomiasis (sleeping sickness)
- T.gambiense (slow, wasting illness), T.rhodesiense (rapidly progressive illness)
- spready by tsetse flies
- tender subcutaneous nodule (chancre) at site of infection
- 2 stages
  i) haemolymphatic
     - fever, rash, rigors, headache, hepatosplenomegaly, lymphadenopathy
     - Winterbottom's sign (posterior cervical node enlargement)
  ii) meningoencephalitic
     - convulsion, agitation, confusion,apathy, depression, ataxia, dementia, hypersomnolence, coma
- treatment: suramin, melarsoprol

 

1 comment:

MATINA said...

I was diagnosed as HEPATITIS B carrier in 2013 with fibrosis of the
liver already present. I started on antiviral medications which
reduced the viral load initially. After a couple of years the virus
became resistant. I started on HEPATITIS B Herbal treatment from
ULTIMATE LIFE CLINIC (www.ultimatelifeclinic.com) in March, 2020. Their
treatment totally reversed the virus. I did another blood test after
the 6 months long treatment and tested negative to the virus. Amazing
treatment! This treatment is a breakthrough for all HBV carriers.