- 4 clinical patterns:
i) amyotrophic lateral sclerosis
ii) progressive bulbar palsy
iii) progressive muscular atrophy - anterior horn cell lesion
iv) primary lateral sclerosis - mainly UMN sign (loss of Betz cell in motor cortex)
- onset more than 50 years of age, with incidence increasing with advancing age
- men affected more frequently
- 5-10% familial (mutation chromosome 21, SOD 1 gene)
- mixed lower motor neuron and upper motor neuron signs
- No sensory loss or sphincter disturbance and never affects eye movement
- 75% presents with limb symptoms, 25% presents with bulbar symptoms (poor prognosis)
- EMG: fasciculation and fibrillation potentials in upper and lower limbs
- El Escorial criteria for ALS (shown below)
- treatment: Riluzole (antiglutamate)
11 comments:
Motor Neuron Disease can lead muscle weakness and wasting. A common medication for MND is “MOTICAL “prescribe by Herbal Care Products which can back off the disease progressions.
Motor Neuron Disease is neurological disorders. Weakness of the muscles is symptoms of motor neuron disease. Natural Treatment depends on its symptoms and reduces causes.
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My mom ALS started out with a foot drop on her left foot. From there her left leg lost all muscle tone and all the entire left leg muscles were almost gone. Also her fingers and thumbs "contract" at times. Left arm is losing muscle tone too,she have been suffering from amyotrophic laterals sclerosis (ALS) disease for the last seven years and had constant pain which really get us worried, especially in her knees, the only treatment for this ALS (amyotrophic lateral sclerosis) is natural organic treatments honestly ,Multivitamin Herbal Care has the perfect herbal remedy to Motor Neuron Disease including,getting into bed was also another thing she finds impossible. We had to find a better solution for her condition which has really helped her a lot,The biggest help we had was multivitamincare .org today (or SMS): +1 -956- 758-7882. They walked us through the proper steps, I highly recommend these herbs to anyone suffering from ALS.
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