- premature epiphyseal closure is a classical feature
- hyperpigmentation and hyperreninaemia
21-hydroxylase deficiency (commonest)
- raised 17 hydroxyprogesterone is diagnostic
- excess androgen production due to shunting of 17 hydroxyprogesterone into testosterone and androstenedione production
- virilisation may result in clitoromegaly and labial fusion in female at birth
11-beta hydroxylase deficiency (second commonest)
- reduced cortisol leads to increse in ACTH and subsequent increase in production of 11-deoxycorticosterone
- diagnosis made by raised 11-deoxycortisol
Treatment of CAH
- replacement with dexamethasone/hydrocortisone
- efficacy of treatment is monitored by 17OH progesterone or androstenedione levels
1 comment:
I was diagnosed as HEPATITIS B carrier in 2013 with fibrosis of the
liver already present. I started on antiviral medications which
reduced the viral load initially. After a couple of years the virus
became resistant. I started on HEPATITIS B Herbal treatment from
ULTIMATE LIFE CLINIC (www.ultimatelifeclinic.com) in March, 2020. Their
treatment totally reversed the virus. I did another blood test after
the 6 months long treatment and tested negative to the virus. Amazing
treatment! This treatment is a breakthrough for all HBV carriers.
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