- a.k.a acute autoimmune inflammatory demyelinating polyneuropathy
- segmental demyelination
- 1-2/100,000/year
- bimodal distribution with peak age 15-35 and 50-75 years
- symmetrical ascending muscle weakness preceded by diarrhea (eg:campylobacter) and chest infection (eg: mycoplasma).
- maximal weakness occurs 2 weeks after initial onset of symptom, weakness almost always symmetrical
- other triggers: HIV,EBV, vaccinations, zoster
- associated with autonomic dysfunction (sweating, tachycardia, BP changes, arrhythmias) and hyporeflexia
- monitor force vital capacity (FVC)
- nerve conduction studies: slow conduction
- CSF: albuminocytological dissociation (raised protein, normal cell count)
- GBS is associated with anti-ganglioside GM1 antibody
- Miller-Fisher variant is associated with anti-G1q antibody
- treatment: IVIG, plasmapheresis
- mortality about 10%
1 comment:
I was diagnosed as HEPATITIS B carrier in 2013 with fibrosis of the
liver already present. I started on antiviral medications which
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became resistant. I started on HEPATITIS B Herbal treatment from
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treatment totally reversed the virus. I did another blood test after
the 6 months long treatment and tested negative to the virus. Amazing
treatment! This treatment is a breakthrough for all HBV carriers.
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