- common complication after stem cell or bone marrow transplantation
- donor cells against normal host organs
- Billingham criteria - 3 criteria must be met in order for GVHD to occur
i) immunocompetent graft is administered with viable and functional immune cells
ii) recipient is immunologically disparate - histo-incompatible
iii) recipient is immunocompromised, therefore cannot inactivate or destroy the transplanted cells
- can be divided into acute (within first 100 days post-transplantation) or chronic
- onset of acute GVHD is usually from day 16 - day 20 as donor marrow engrafts and the neutrophils count rises
- acute GVHD causes a skin rash (typically commencing on palms and soles), diarrhea and jaundice
- more common after unrelated donor transplantation
- initial treatment of acute GVHD is high dose methylprednisolone. If no response, consider antilymphocyte globulin
2 comments:
I was diagnosed as HEPATITIS B carrier in 2013 with fibrosis of the
liver already present. I started on antiviral medications which
reduced the viral load initially. After a couple of years the virus
became resistant. I started on HEPATITIS B Herbal treatment from
ULTIMATE LIFE CLINIC (www.ultimatelifeclinic.com) in March, 2020. Their
treatment totally reversed the virus. I did another blood test after
the 6 months long treatment and tested negative to the virus. Amazing
treatment! This treatment is a breakthrough for all HBV carriers.
Great post, much appreciate the time you took to write this
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