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Monday 28 May 2012

Stiff person syndrome

- spontaneous discharge of the motor neurons of the spinal cord cause involuntary muscle contractions mainly involving the axial (trunk) and proximal lower extremity muscles
- gait becomes more stiff and labored, with hyperlordosis of lumbar spine
- superimposed episodic muscle spasms are precipitated by sudden movements, unexpected noises and emotional upset
- serum antibodies against glutamic acid decarboxylase are present in approximately 2/3 of cases
- treatment is mostly palliative with muscle relaxant with potentiate GABA actions (such as benzodiazepines)

1 comment:

Oscar said...

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