- heralded by livedo reticularis and advances to patches of ischemic necrosis especially on the legs, thighs, abdomen and breasts
- pathologically, there is vascular occlusion associated with extensive vascular (calcification of tunica media) and soft tissue calcification
- warfarin is a risk factor of calciphylaxis ( because warfarin decrease vitamin K dependent regeneration of matrix GLA protein which is important in preventing vascular calcification)
- optimal treatment is prevention, with rigorous and continuous control of phosphate and calcium balance
- no specific treatment
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