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Sunday 4 September 2011

juvenile myoclonic epilepsy

- most common primary generalised epilepsy
- genetically linked to short arm of chromosome 6
- absence seizure during childhood
- in adolescent, presents with myoclonic jerks in the morning after waking (Kellogg's jerk) and generalised tonic clonic seizure.
- worsened by sleep deprivation and alcohol
- EEG: generalised spike and polyspike wave activity
- treatment: valproate (extremely respond well) and lamotrigine (lower rate of drug interaction)
- lifelong drug treatment is usually necessary to avoid relapse in patients who achieve seizure free status on medication

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