- focal disorder of bone remodelling
- most are asymptomatic and incidence up to 10% of individuals radiologically affected by age of 90
- symptoms: bone pain, bowed tibia, skull changes, joint pain (when bone involved close to joint)
- most common site = pelvis
- complications: nerve compression (deafness from CN VIII involvement), high output cardiac failure, pathological fracture, osteosarcoma
- X-ray: osteoporosis circumscripta in skull is characteristic
- raised ALP and normal calcium & phosphate
- treatment: bisphosphonates
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