Erythema gyratum repens

- characteristic concentric erythematous bands forming a wood-grain appearance
- associated with malignancy in up to 80% of patients
- most develop the eruption before the symptoms of malignancy

POEMS syndrome

- rare multisystem disease that occurs in the setting of plasma cell dyscrasia

- P - polyneuropathy (symmetrical and distal)

  O - organomegaly (liver, spleen and lymph nodes)

  E - endocrinopathy

  M - monoclonal gammopathy

  S - skin abnormalities (hyperpigmentation and hypertrichosis)

T-score interpretation

Ann Arbor staging

Warfarin reversal guideline

Warfarin reversal: consensus guidelines, on behalf of the Australasian Society of Thrombosis and Haemostasis. MJA 2004

CURB-65 scoring

Ethylene glycol poisoning

- commonly used as a coolant and preservative and is found in polishes and detergents

- ethylene glycol poisoning often exhibits three distinct clinical phases after ingestion due to toxic metabolites glycolate, glyoxalate and oxalate

- first 12 hours - CNS effect predominate, patient appears intoxicated

- 12-24 hours - cardiopulmonary effect predominate, tachycardia, tachypnea and raised BP are common

- 24-72 hours - renal effects predominate

- hypocalcemia may result from precipitation of calcium oxalate in tissues and may be severe enough to cause tetany and typical ECG changes

- high anion gap metabolic acidosis

- treatment: gastric lavage within 1 hour of ingestion

- inhibit metabolism with intravenous ethanol (competitive inhibitor of alcohol dehydrogenase). Ethanol requires treatment on the ITU because of risk of respiratory depression

- fomepizole is an alternative treatment, being more potent than ethanol but generally more expensive

Sarcoidosis

- multisystem granulomatous disorder of unknown cause
- prevalence highest in Northern Europe
- 20-40% asymptomatic, discovered incidentally after routine CXR
- acute sarcoidosis presents with erythema nodosum and polyarthralgia which resolves spontaneously
- serum ACE elevated in 60% of patients, presumably reflecting macrophage activity
- transbronchial biopsy provide positive histology in 80% of patients
- Kveim reaction, a granulomatous reaction appearing 4 weeks after intradermal injection of sarcoid spleen or lymph node extract is positive in 50-60% of patients
- Mikulicz syndrome : sarcoidosis with parotid gland enlargement
- Heerfordt's syndrome (uveoparotid fever) : Mikulicz syndrome with acute uveitis and facial nerve palsy

Refsum's disease

- autosomal recessive disorder
- caused by defective alpha oxidation of phytanic acid leading to its accumulation in tissues
- onset normally in late teens or 20s
- characterised by sensorimotor peripheral neuropathy, sensorineural deafness, anosmia, cerebellar ataxia, pes cavus, night blindness (retinitis pigmentosa), cardiac conduction abnormalities, epiphyseal dysplasia (shortening of 4th toe)
- elevated serum phytanic acid level
- treatment: dietary restriction of foods containing phytanic acid (chlorophyll)

Dextrocardia

ECG findings of dextrocardia
- right axis deviation
- positive QRS complex in aVR
- lead I : global negativity (inversion of all complexes)
- absent R wave progression in chest leads (dominant S wave throughout)