- multisystem granulomatous disorder of unknown cause
- prevalence highest in Northern Europe
- 20-40% asymptomatic, discovered incidentally after routine CXR
- acute sarcoidosis presents with erythema nodosum and polyarthralgia which resolves spontaneously
- serum ACE elevated in 60% of patients, presumably reflecting macrophage activity
- transbronchial biopsy provide positive histology in 80% of patients
- Kveim reaction, a granulomatous reaction appearing 4 weeks after intradermal injection of sarcoid spleen or lymph node extract is positive in 50-60% of patients
- Mikulicz syndrome : sarcoidosis with parotid gland enlargement
- Heerfordt's syndrome (uveoparotid fever) : Mikulicz syndrome with acute uveitis and facial nerve palsy
2 comments:
Sarcoidosis can affect any organ in your body.Its starts in the lungs, skin and lymph nodes.Symptoms are Weight loss, fatigue, night sweats and fever.Hope this hints will be helpful to revise. Know more
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