- over 95% patients with PV have acquired mutations of the gene Janus Kinase 2 (JAK2)
- presents with lethargy, depression, vertigo, itching, gout and visual disturbance
- ruddy cyanosis, plethoric conjunctiva, hypertension, hepatosplenomegaly
- Hb, PCV and RCV are increased
- increased NAP score
- 30% develops myelofibrosis and 5% develop AML
- major complication is bleeding and thrombosis
- treatment: venesection (400-500ml per week, aim PCV < 0.45) or hydroxyurea, H2 receptor antagonist for itchiness, low dose aspirin to prevent thrombosis
1 comment:
I was diagnosed as HEPATITIS B carrier in 2013 with fibrosis of the
liver already present. I started on antiviral medications which
reduced the viral load initially. After a couple of years the virus
became resistant. I started on HEPATITIS B Herbal treatment from
ULTIMATE LIFE CLINIC (www.ultimatelifeclinic.com) in March, 2020. Their
treatment totally reversed the virus. I did another blood test after
the 6 months long treatment and tested negative to the virus. Amazing
treatment! This treatment is a breakthrough for all HBV carriers.
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