- strongly associated with HLA-DR2 and HLA-DQB1*0602 antigen
- caused by loss of hypothalamic neuropeptide orexin. Orexins are released from synaptic terminals during wakefulness and increase the activity of brain regions associated with wakefulness.
- characterised by excessive daytime somnolence associated with cataplexy, hypnogogic or hypnopompic hallucination and sleep paralysis (classic tetrad)
- multiple sleep latency test EEG during the day shows rapid onset of REM sleep (less than 10 minutes after onset of sleep)
- treatment: non-pharmacological (sleep timetable, reduce alcohol intake); CNS stimulants (methylphenidate, amphetamine), modafinil
ReplyDeleteI was diagnosed as HEPATITIS B carrier in 2013 with fibrosis of the
liver already present. I started on antiviral medications which
reduced the viral load initially. After a couple of years the virus
became resistant. I started on HEPATITIS B Herbal treatment from
ULTIMATE LIFE CLINIC (www.ultimatelifeclinic.com) in March, 2020. Their
treatment totally reversed the virus. I did another blood test after
the 6 months long treatment and tested negative to the virus. Amazing
treatment! This treatment is a breakthrough for all HBV carriers.