- male:female = 4:1
- hairy cells are larger than lymphocytes, their nuclei show a homogenous loose chromatic pattern without a visible nucleolus and cells have abundant cytoplasm with broad base projection or villi, nuclear outline is often kidney shape
- presents with pancytopenia and massive splenomegaly
- associated with monocytopenia (typical finding)
- skin vasculitis (erythema nodosum & cutaneous nodules) in one third of patients
- bone marrow trephine biopsy: characteristic clear zone between cell (fried egg appearance)
- increased bone marrow reticulin often results in dry tap marrow aspirate despite marrow hypercellularity
- abnormal cells are strongly positive for tartrate resistant acid phosphatase strain (TRAP)
- respond dramatically to purine analogues (cladribine and pentostatin), with survival rate at 5 years
of 95-95%
ReplyDeleteI was diagnosed as HEPATITIS B carrier in 2013 with fibrosis of the
liver already present. I started on antiviral medications which
reduced the viral load initially. After a couple of years the virus
became resistant. I started on HEPATITIS B Herbal treatment from
ULTIMATE LIFE CLINIC (www.ultimatelifeclinic.com) in March, 2020. Their
treatment totally reversed the virus. I did another blood test after
the 6 months long treatment and tested negative to the virus. Amazing
treatment! This treatment is a breakthrough for all HBV carriers.