Mesangiocapillary glomerulonephritis (MCGN)

- Type I: associated with mesangial cell proliferation and mainly subendothelial immune complex deposition (tramline appearance). Associated with hepatitis B or C infection and reduced plasma C3, C4. Classical complement activation (reduced C4 levels)
  Type I more common than type II

- Type II: idiopathic or after measles infection. Characterised by mesangial cell proliferation with electrodense, linear intramembranous deposits that stain positive for C3. Presents with hematuria, proteinuria, nephrotic syndrome or renal failure.
   Immune complex deposition is predisposed to by C3 nephritic factor rise in MCGN type II, which stabilise C3bBb and activates the alternative complement pathway