Drug induced lupus

- more common in caucasian
- typically presents with myalgia and arthralgia
- risk factors: HLA-DR4, slow acetylator status (autosomal recessive), large total daily dose of precipitating drug
- common drugs: hydralazine, isoniazide, procainamide (highest risk), penicillamine, chlorpromazine, minocycline, simvastatin, captopril
- pulmonary and skin involvement is common, renal and CNS rarely affected
- positive antihistone antibodies
- treatment: discontinue the medication