MRCP revision

Calculated A-a gradient =  150mmHg - PaCO2/0.8 - PaO2 Expected A-a gradient = Age/4 + 4 Normal A-a gradient suggest hypovent...

Mnemonics Marfan's syndrome : chromosome 15 (15 alphabates) APKD 1 ( Polycystic kidney ) : chromosome 16 (16 alphabates) Neurofibrom...

- found on chromosome 6 - HLA corresponds to MHC class I (A,B and C) - HLA corresponds to MHC class II (D) HLA associations - HLA DR2 :...

- 2 main incretins, GLP-1 (glucagon-like peptide-1) and GIP (glucose dependent insulinotropic peptide) - secreted by L cells of ileum and...

Polymyositis - reduced amplitude and duration of motor units Motor neurone disease - fibrillation due to denervation Myasthenia gravis - d...

- H erpesvirus - H epadnavirus - A denovirus - P apovavirus - P ox virus - P arvovirus All DNA viruses are double stranded except Par...

- Proto-oncogenes found in normal human genomes, have a central role in signal transduction pathway that control cell growth and differentia...

- triad of Dermatitis, Dementia and Diarrhea - caused by niacin deficiency - redness, cracks, chronic thickening, dryness and pigmentatio...

GLUT-1 : basal non-insulin-stimulated glucose uptake into many cells GLUT-2 : glucose sensing (glucose transport into beta cells ) GLUT-...

- programmed cell death - features: cell shrinkage, compaction of chromatin, nuclear blebbing, cell fragmentation, energy dependent process...

- rare immunodeficiency due to a defect in neutrophil killing and characterised by deep seated infection - defect in production of NADPH-ox...

Zinc deficiency - acrodermatitis enteropathica is an inherited disorder caused by malabsorption of zinc - causes dermatitis , growth retar...

- X-linked defect in CD40 ligand - B cells are trapped at immature level producing only IgM - Levels of other types of immunoglobulin are ...

Southern blot : DNA analysis (detection of specific DNA sequence) Northern blot : RNA analysis Western blot :   Protein analysis Ea...

- located in cytoplasm - coupled to transmembrane receptor (G protein coupled receptor) - seven helical membrane receptors - ligand bindin...

- X linked recessive - mutation in WASP gene - triad of pyogenic infection, eczema and thrombocytopenia - due to lack of sialophorin, pr...

Live vaccines (to be avoided in immunocompromised patient) " MMR BOY" MMR : measles, mumps, rubella B : BCG O : oral polio (...

- most common primary immunodeficiency - typically present at any age with recurrent infections caused by pyogenic organisms and affecting ...