- 3 cardinal signs : resting tremor, rigidity and bradykinesia
- 2 of 3 including bradykinesia are required to make a clinical diagnosis
- medical therapy of PD
~ Levodopa
- for older patient
- risk risk of disease acceleration and motor fluctuations & dyskinesia
~ Dopamine agonist (ropinirole, pramipexole)
- for younger patients
- used as monotherapy to delay starting L-dopa in early stage of PD
- lower risk of dyskinesia
~ COMT inhibitor (entacapone)
~ MAO-B inhibitor (selegiline)
~ anticholinergic (benzhexol) - improve tremor and sialorrhea
~ apomorphine
- DaT (dopamine transporter) scan helps to differentiate PD from essential tremor
- deep brain stimulation or pallidotomy when medical therapy fails
Parkinson's disease is a chronic and progressive disorder. There are almost millions off of people only in the US are suffering from Parkinson's disease and the patient of this disease are increasing day by day. Though there is no treatment for this disease, the scientists are trying the new idea for treatment of Parkinson's disease. Parkinson's disease treatment
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