Tuesday, 6 December 2011

Botulism

- paralytic disease caused by neurotoxins of Clostridium botulinum
- due to inhibition of acetylcholine release at neuromuscular junction
- associated with trauma, surgery, subcutaneous heroin injection and sinusitis from intranasal cocaine abuse
- incubation period is 4-14 days
-  cranial nerves, bulbar, symmetrical paralysis (diplopia, dysarthria, dry mouth, generalised weakness)
- respiratory failure arises from airway obstruction and diaphragmatic weakness
- diagnosis confirmed by isolation of toxin from serum
- antitoxin is avaiable but risk of anaphylaxis



1 comment:

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    treatment totally reversed the virus. I did another blood test after
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    ReplyDelete