Tuesday, 1 November 2011

Serotonin syndrome

- toxic hyperserotonergic state can be caused by ingestion of 2 or more drugs that increase serotonin levels (eg: SSRI with MAOI, dopaminergic drug or TCA)
- presents with agitation, confusion, tremor, diarrhea, tachycardia, hypertension and hyperthermia
- treatment: supportive,removal of causative agent, drugs with serotonin antagonist activity (cyproheptadine, methysergide)

1 comment:


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