Sunday, 27 November 2011

Methaemoglobinaemia

- caused by either genetic defect in red cell metabolism or haemoglobin structure or acquired by a variety of drugs and toxins
- results from oxidation of ferrous iron in haemoglobin to ferric form
- oxygen-hemoglobin dissociation curve shifts to left
- causing precipitation as Heinz bodies and eventually leads to hemolytic anemia
- common drugs: dapsone, nitrates, antimalarials, sulphonamides and dyes
- presents with cyanosis, SOB, mental status change, headache, dizziness, arrhythmias, seizures
- chocolate brown blood
- low SaO2 (on oximeter) but good PO2 (ABG)
- treatment: methylene blue 1-2mg/kg and oxygen, ascorbic acid as second line drug

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1 comment:

  1. MATINA3 July 2021 at 17:07


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