- due to immune response directed against heparin/platelet factor 4 complexes
- paradoxially associated with severe thrombosis (most commonly DVT)
- thrombosis results from IgG-induced platelet activation (via platelet Fc receptor) which leads to generation of procoagulant, platelet derived microparticles.
- Type 1 HIT (non-immune) presents with first 2 days after exposure, platelet count normalised with continued heparin therapy (rarely falls below 100 X 10^9/L in type 1). Type 2 HIT (immune mediated) is the serious type with thrombotic complications.
- presence of anti-PF4-heparin antibodies
- alternative anticoagulation: heparinoid danaparoid or direct thrombin inhibitor hirudin
(avoid warfarin - risk of warfarin necrosis)
ReplyDeleteI was diagnosed as HEPATITIS B carrier in 2013 with fibrosis of the
liver already present. I started on antiviral medications which
reduced the viral load initially. After a couple of years the virus
became resistant. I started on HEPATITIS B Herbal treatment from
ULTIMATE LIFE CLINIC (www.ultimatelifeclinic.com) in March, 2020. Their
treatment totally reversed the virus. I did another blood test after
the 6 months long treatment and tested negative to the virus. Amazing
treatment! This treatment is a breakthrough for all HBV carriers.