Tuesday, 11 October 2011

Palmar crease xanthoma

- pathognomonic of type III hyperlipidemia (Broad beta disease / remnant hyperlipidemia / familial dysbetalipoproteinemia) - autosomal recessive
- caused by deficiency of apoliproprotein E (ligand for chylomicron)
- characterised by increased LDL, triglyceride and cholesterol, decreased HDL
- have elevation of IDL, a VLDL remnant
- diagnosed by lipoprotein electrophoresis or genotyping of apoprotein E
- also presents with tuboeruptive xanthoma

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6 comments:

  1. melody12 October 2011 at 10:50

    Which type of dyslipaedemia carries higher risk of cvs complication? Familial hypercholeterolemia vs type III hyperlipid?

    ReplyDelete
  2. melody12 October 2011 at 18:02

    Which one will increase cvs risk more? Type III hyperlipid vs familial hypercholesterol?

    ReplyDelete
  3. KIM, ALEX13 October 2011 at 00:12

    Familial hypercholesterolemia associated with premature CVS disease. Caused by LDL receptor dysfunction.Less common than familial combined hyperlipidemia.

    ReplyDelete
  4. Fishydishy2 March 2014 at 21:18

    Silly I know but -

    P III, with lumps on knee from loss of E.

    ReplyDelete
  5. Bronya B7 June 2017 at 03:38

    Fishydishy -- that is actually pretty neat! Thanks! (And thank you, too, Blogger!)

    ReplyDelete
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    ReplyDelete