Mitral valve prolapse (MVP)

- posterior bulging of leaflets of mitral valve in systole
- occurs in 5% of population, usually female with narrow AP chest diameter
- presents with chest pain, palpitation or fatigue
- association: Marfan's syndrome, ASD, pseudoxanthoma elasticum, Ehler's Danlos syndrome, WPW syndrome, HCM, SLE, autoimmune thyroid disease
- mid to late systolic click and murmur (squatting increase click, standing increase murmur)
- myxomatous degeneration and redundant valve tissue due to deposition of acid mucopolysaccharide material
- sequelae (less than 1% per year): embolic phenomena, rupture of mitral valve chordae, risk of endocarditis, prolonged QT, sudden death
- treat with beta blocker if there is symptoms of dysautonomia (eg: palpitation, chest pain)