Autoimmune polyendocrine syndrome

Type 1
- autosomal recessive, rare
- mutation of AIRE gene on chromosome 21
- hypoparathyroidism, addison's disease, chronic mucocutaneous candidiasis
- other associations : hypogonadism, pernicious anemia, hypothyroidism, vitiligo, alopecia, chronic active hepatitis

Type 2 (Schmidt's syndrome)
- Addison's disease, type 1 DM, autoimmune thyroid disease
- other associations: hypogonadism, vitiligo, alopecia, pernicious anemia, chronic active hepatitis, atrophic gastritis, coeliac disease, dermatitis herpetiformis