Behcet's disease

- Triad of aphthous (oral) ulcer + painless genital lesions + recurrent eye inflammation (iritis/uveitis)
- associated with HLA B5 (ocular disease) & HLA B12 (oral ulcer)
- other features: arthritis, erythema nodosum, abdominal pain (intestinal erosion or ulcer), diarrhea, cranial nerve palsies, aseptic meningitis, seizure
- it is the only vasculitic disease that involve both the arterial and venous system
- vascular thrombosis in 10%
- Pathergy test (small red bump/pustule at site of needle insertion in 48 hours)
- treatment : steroid, colchicine